Yasmin (Drospirenone/Ethinyl Estradiol)

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In recent years oral contraception is rapidly gaining popularity. Choosing a contraceptive is a very serious issue, which should be carried out exclusively under your gynecologist supervision. One of the most popular contraceptives is Yasmin – a new-generation birth control pill.

It is a modern medication intended for pregnancy prevention and menstrual cycle stabilization for women aged 18 to 40 years old. The drug is recommended to take repeatedly because the first dose already causes significant changes in the cervix.

Structure and Composition

Yasmin contains 2 active ingredients: ethinylestradiol and drospirenone, which affect egg and inhibit ovulation process. 3 mg pills covered with a white coating. One blister contains 3 weeks dosage.

Pharmacological Properties

The hormonal targeted agent immediately affects cervical microflora. Because of uterine mucus and main preparation components reaction, cervical secretion glands performance slows down. Cervix, lacking the required amount of nutrients and mucus, becomes inaccessible for sperm cells. The drug is effective at 87% of cases, contraception has a positive effect on the endocrine profile. Drospirenone is useful for patients suffering from a hormonal balance disorder, including neuro-psychological forms.

Indications

Yasmin contraceptive administered in the following cases:

  1. prevention of unwanted pregnancies;
  2. menstrual cycle disorders;
  3. acne;
  4. edema.

Hormonal contraception is also effective at excessive breast engorgement.

Specific Recommendations

Yasmin contraceptive pills are a monophasic type of contraceptives, so before applying it is necessary to consult a gynecologist. Irregular hemorrhages during the early weeks of use is a normal phenomenon, which gradually stabilizes.

Dosage and Administration

Medication is taken 1 pill once a day strictly at one and the same time. When missing or reception regimen violation negative consequences for the body may occur. After 21 days a 7-day break is necessary, after which standard dosage is repeated. During this break, vaginal hemorrhage is a normal reaction. Contraception restores the regular menstrual cycle.

Contraindications

Generic Yasmin should not be used if you have any disorders listed below. If any of them appear for the first time while using the drug, it should be immediately canceled.

  • thrombosis (venous and arterial) present or in anamnesis (e. g., deep venous thrombosis, pulmonary artery thromboembolism, myocardial infarction, cerebrovascular events);
  • severe or multiple risk factors of venous or arterial thrombosis;
  • conditions followed by thrombosis present or in anamnesis (e. g., transient ischemic attack, cardiac angina);
  • diabetes with vascular complications;
  • severe hepatic disorders present or in anamnesis (until liver function tests return to normal);
  • severe or acute nephrotomy;
  • hepatic tumors present or in anamnesis (benign or malignant);
  • present or suspected hormone-dependent malignant genital or breast diseases;
  • vaginal hemorrhage of unknown origin;
  • present or suspected pregnancy;
  • lactation period;
  • hypersensitivity to any drug component.

Side Effects

During the first days of use, a woman may get pseudo menstruation. When receiving Yasmin pills, the cycle flows normally, without complications and abdominal pains. Often this medication is taken to control the menstrual cycle, in particular, to reduce pain. Do not stop taking this medication after vaginal hemorrhage appearance in order to avoid serious complications in the uterus.

Negative side effects include:

  • dizziness;
  • sickness;
  • vomiting;
  • abdominal pains;
  • dyspnea;
  • strong expectorant cough with blood (recommended immediately call an ambulance);
  • insomnia;
  • allergic reactions.

Interactions

Drug interactions that result in increased sex hormones clearance can lead to breakthrough bleeding or decreased contraceptive effect. This fact was established concerning hydantoin, barbiturates, primidone, carbamazepine, and rifampicin; there are also suggestions concerning oxcarbazepine, topiramate, felbamate, and griseofulvin. This interaction mechanism is based on changes in liver enzymes’ performance. Maximal enzyme induction is usually not apparent during 2 – 3 weeks, but then may be stored for at least four weeks after the drug therapy cessation. The contraceptive reliability is reduced when it’s taken with antibiotics, such as ampicillin and tetracycline. This action mechanism has not been yet studied.

Women taking any of the above drugs in a short course in addition to Yasmin should temporarily use barrier contraception methods during concurrent medication administration and for 7 days after their withdrawal. While receiving rifampicin and 28 days after its withdrawal in addition to generic Yasmin barrier contraception method (such as condoms) should be applied. If concurrent drug therapy was started at the end of Yasmin pack, the next pack should be started without the usual 7-days break.

Women, for a long time receiving drugs that affect liver enzymes, should consider other contraception methods.

Other Interactions

There is a theoretical possibility of serum potassium level increase at women receiving Yasmin together with other drugs that may increase serum potassium level. These drugs include ACE inhibitors (angiotensin-converting enzyme), angiotensin-2 receptor antagonists, some anti-inflammatory drugs (e. g., indomethacin), potassium-sparing diuretics, and aldosterone antagonists. However, the study assessing the interaction between the ACE inhibitor and combination of drospirenone/estradiol at women with mild arterial hypertension showed no significant difference between serum potassium concentration at women receiving enalapril compared to placebo.

Effects on Laboratory Tests

Sex steroids administration may influence biochemical function indicators of the liver, thyroid body, adrenal body, and kidneys as well as transport plasma protein levels, such as corticosteroid-binding protein and lipid/lipoprotein fractions, carbohydrate metabolism indicators, coagulation and fibrinolysis. Changes usually occur within laboratory standards. Because of its anti-aldosterone activity, drospirenone increases blood plasma rennin and aldosterone activity.

Overdose

No serious side effects at overdose have been reported. Symptoms that may occur in this case are:

  • sickness;
  • vomiting;
  • slight vaginal hemorrhage.

There is no specific antidote; symptomatic treatment is recommended.

Yasmin and Weight Loss

Many women suffer from a number of difficulties while taking birth control pills. One of them is weight gain, which is the most frequently observed side effect of all oral contraceptives. The reason is that all birth control pills contain estrogen hormone.

Recently mass media declared news that contraceptive pills that contribute to weight loss finally appeared. They are called Yasmin and were invented in the USA. The drug popularity has greatly increased after announcing this study results, which involved 300 women who lost at average 3-5 kg after taking Yasmin for six months. Yasmin contains ingredients (unlike other female birth control pills) that have a diuretic effect and prevent water retention.

URL Pharma emphasizes that Yasmin is designed to prevent pregnancy but not to lose weight.